http://starc.stthomas.ac.in:8080/xmlui/xmlui/handle/123456789/369 2026-04-09T08:57:33Z http://starc.stthomas.ac.in:8080/xmlui/xmlui/handle/123456789/370 Adverse Drug Reactions (ADR) necessitating modification of multi-drug therapy (MDT) in Hansens disease: a retrospective study from Kerala, India Ambooken, Betsy; George, Sandhya; Azeez, Neema; Asokan, N; Xavier, TD Objective: To assess the frequency and type of adverse drug reactions (ADR) that necessitated modification of multi-drug therapy (MDT) in Hansen’s disease, with emphasis to find out the interval between initiation of MDT and the occurrence of ADR. Design: A retrospective analysis of case records of patients diagnosed with Hansen’s disease (HD) and registered for MDT in a tertiary care institution between 2010 and 2015. Clinical details and laboratory data were collected using a proforma. Results: One hundred and ninety-six patients were registered for treatment during the study period. We analysed 150 records that met the inclusion criteria. Thirty-six among them (24%) had ADR that needed modification of MDT. The most common ADR was haemolytic anemia (19 patients; 12.7%) followed by hepatitis (14 patients; 9.3%). The most serious ADR was agranulocytosis (three patients; 2%). Adverse effects were more common (72%) during the initial 2 months of MDT compared to later months. (P = 0.004). 2017-06-01T00:00:00Z